Wąż Piotr, Bielińska-Wąż Dorota
Department of Nuclear Medicine, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.
Department of Radiological Informatics and Statistics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.
Genomics. 2014 Dec;104(6 Pt B):464-71. doi: 10.1016/j.ygeno.2014.08.010. Epub 2014 Aug 28.
Similarity/dissimilarity analysis of DNA sequences is performed using 3D-dynamic representation. The sequences are represented by material points in a 3D-space. Descriptors related to such 3D-dynamic graphs are calculated. A new normalized similarity measure is introduced for a comparison of the sequences. The method is applied to β-globin (HBB) genes of different species. Different methods are compared. The multidimensionality of similarity space of complex objects is discussed (different results for each of the methods). It is also shown that it is easier to find the properties which are consistent with the observation of the evolution of the species for the second exons of β-globin gene rather than for the first ones.
使用三维动态表示法对DNA序列进行相似性/相异性分析。这些序列由三维空间中的物质点表示。计算与此类三维动态图相关的描述符。引入一种新的归一化相似性度量用于序列比较。该方法应用于不同物种的β-珠蛋白（HBB）基因。比较了不同方法。讨论了复杂对象相似性空间的多维性（每种方法的结果不同）。还表明，相较于β-珠蛋白基因的第一个外显子，更容易找到与物种进化观察结果一致的第二个外显子的特性。
