长期感染R5嗜性猿猴-人类免疫缺陷病毒的猪尾猕猴发生肺动脉大面积闭塞性血栓形成。
Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus.
作者信息
Courtney Cynthia L, Ethun Kelly F, Villinger Francois, Ruprecht Ruth M, Byrareddy Siddappa N
机构信息
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Pathology & Laboratory Medicine, School of Medicine and Emory Vaccine Center, Emory University, Atlanta, GA, USA.
出版信息
J Med Primatol. 2015 Feb;44(1):35-9. doi: 10.1111/jmp.12142. Epub 2014 Sep 1.
Abstract
BACKGROUND
Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection.
METHODS AND RESULTS
Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals.
CONCLUSION
This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.
摘要
背景
肺动脉高压（PAH）已被确认为HIV感染的一种严重并发症。
方法与结果
在此，我们报告了两只慢性感染（感染后约1 - 2年）R5 SHIV毒株的猪尾猕猴（食蟹猴）突然死亡的情况。尸检时，两只动物的肺动脉均被一个大的纤维蛋白血栓完全阻塞。
结论
本报告描述了R5 SHIV感染的猪尾猕猴中与PAH相似的肺血管病变。
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