Xu W, Yan Y S, Chen Z Q
Zhen Ci Yan Jiu. 1989;14(4):428-30.
There were different opinions about whether ketamine has an antagonistic effect on electroacupuncture (EA) analgesia. The aim of this paper was to investigate the effect of ketamine on EA. The rats were divided into three groups: 4 mg/kg, 20 mg/kg of ketamine in doses, and normal saline groups. Ketamine was injected peritoneally in dosage of 4 mg/kg and 20 mg/kg respectively. Tail flick latency (TFL) and vocalization threshold (VT) were taken as the indices of pain responses. Changqiang and Yaoshu acupoints were selected for electroacupuncture. It was observed that the analgesia effects of EA were attenuated after injection of ketamine either in 4 mg/kg group of 20 mg/kg group. The results indicate that 4 mg/kg or 20 mg/kg ketamine in doses has an antagonistic effect on EA analgesia, suggesting that attention should be paid to the dosage when ketamine is used for EA analgesia.
关于氯胺酮对电针镇痛是否具有拮抗作用存在不同观点。本文旨在研究氯胺酮对电针的影响。将大鼠分为三组：4毫克/千克、20毫克/千克氯胺酮剂量组和生理盐水组。分别以4毫克/千克和20毫克/千克的剂量腹腔注射氯胺酮。采用甩尾潜伏期（TFL）和发声阈值（VT）作为疼痛反应指标。选取长强穴和腰俞穴进行电针。观察到无论是4毫克/千克组还是20毫克/千克组，注射氯胺酮后电针的镇痛效果均减弱。结果表明，4毫克/千克或20毫克/千克剂量的氯胺酮对电针镇痛具有拮抗作用，提示在氯胺酮用于电针镇痛时应注意剂量。
