用于检测蛋白酶的寡肽修饰液晶液滴
Oligopeptide-decorated liquid crystal droplets for detecting proteases.
作者信息
Chang Chung-Yun, Chen Chih-Hsin
机构信息
Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan.
出版信息
Chem Commun (Camb). 2014 Oct 18;50(81):12162-5. doi: 10.1039/c4cc04651j.
PMID:25177752
Abstract
We prepared the bioactive liquid crystal (LC) droplets by decorating an oligopeptide at the LC/aqueous interface to stabilize the LC droplets. These LC droplets can be used to detect proteases through the specific cleavage of protease on an oligopeptide leading to a bipolar-to-radial transition of LC configuration inside the droplets.
摘要
我们通过在液晶/水界面修饰一种寡肽来制备生物活性液晶（LC）微滴，以稳定LC微滴。这些LC微滴可用于检测蛋白酶，因为蛋白酶对寡肽的特异性切割会导致微滴内部LC构型从双极向径向转变。
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