Misso Marie L, Teede Helena J
Monash Centre for Health Research and Implementation, School Public Health and Preventative Medicine, Monash University, MHRP, 43-51 Kanooka Grove, Clayton, VIC, 3168, Australia,
Endocrine. 2015 Mar;48(2):428-33. doi: 10.1007/s12020-014-0394-8. Epub 2014 Sep 2.
Metformin has a potential role for insulin resistance in polycystic ovary syndrome(PCOS) and has demonstrated efficacy in diabetes. There are a large number of studies and evidence syntheses comparing metformin with control, lifestyle interventions, the oral contraceptive pill, and clomiphene citrate; however, there is still uncertainty about the effectiveness of metformin in women with PCOS. Here we present a systematic overview of the evidence for the use of metformin in women with PCOS. The evidence suggests that metformin continues to have an unclear roll in PCOS until further well designed; methodologically rigorous effectiveness studies with large sample sizes are conducted, and these should include women across the body mass index (BMI) range.
二甲双胍在多囊卵巢综合征（PCOS）的胰岛素抵抗方面具有潜在作用，并且已在糖尿病治疗中显示出疗效。有大量研究和证据综述比较了二甲双胍与对照组、生活方式干预、口服避孕药以及枸橼酸氯米芬；然而，二甲双胍对PCOS女性的有效性仍存在不确定性。在此，我们对二甲双胍用于PCOS女性的证据进行系统综述。证据表明，在进一步开展设计良好、方法严谨且样本量足够大的有效性研究之前，二甲双胍在PCOS中的作用仍不明确，这些研究应涵盖不同体重指数（BMI）范围的女性。
