用于膜蛋白研究的基于金刚烷的两亲分子（ADAs）：去污剂疏水基团在膜蛋白溶解中的重要性。
Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation.
作者信息
Chae Pil Seok, Bae Hyoung Eun, Das Manabendra
机构信息
Department of Bionanotechnology, Hanyang University, Ansan, 426-791, Korea.
出版信息
Chem Commun (Camb). 2014 Oct 21;50(82):12300-3. doi: 10.1039/c4cc05746e.
PMID:25178798
Abstract
We prepared adamantane-containing amphiphiles and evaluated them using a large membrane protein complex in terms of protein solubilisation and stabilization efficacy. These agents were superior to conventional detergents, especially in terms of the membrane protein solubilisation efficiency, implying a new detergent structure-property relationship.
摘要
我们制备了含金刚烷的两亲分子，并使用一种大型膜蛋白复合物对其在蛋白质增溶和稳定功效方面进行了评估。这些试剂优于传统去污剂，尤其是在膜蛋白增溶效率方面，这意味着一种新的去污剂结构-性质关系。
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