原发性和继发性干燥综合征患者唾液腺蛋白1抗体的评估
Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.
作者信息
Shen Long, Kapsogeorgou Efstathia K, Yu Meixing, Suresh Lakshmanan, Malyavantham Kishore, Tzioufas Anthanasios G, Ambrus Julian L
机构信息
Division of Allergy, Immunology and Rheumatology, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Department of Pathophysiology, National University of Athens, Athens, Greece.
出版信息
Clin Immunol. 2014 Nov;155(1):42-46. doi: 10.1016/j.clim.2014.08.009. Epub 2014 Aug 30.
Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
干燥综合征（SS）与抗Ro和抗La抗体的表达有关。最近在干燥综合征患者中发现了抗唾液腺蛋白1（SP1）抗体。目前的研究是一项横断面研究，旨在确定在特定亚组的干燥综合征患者中是否能检测到抗SP1抗体。这项研究的结果显示，52%的干燥综合征患者血清中存在抗SP1抗体，而63%的患者存在抗Ro/抗La抗体。19%的患者有抗SP1抗体但无抗Ro/抗La抗体。干燥综合征合并淋巴瘤的患者同时表达抗Ro、抗La和抗SP1。在与类风湿关节炎相关的干燥综合征中，50%的患者有抗SP1抗体，40%的患者有抗Ro/抗La抗体。总之，抗SP1抗体在原发性和继发性干燥综合征中均常见，而在正常对照中罕见。需要进一步研究以确定抗SP1抗体在干燥综合征中的作用及表达时机。
Zotero 插件