Nakhle M C, de Menezes M da C, Irulegui I
Rev Inst Med Trop Sao Paulo. 1989 Nov-Dec;31(6):384-91. doi: 10.1590/s0036-46651989000600004.
Eosinophil dynamics, in bone marrow, blood and peritoneal exudate, of resistant C57B1/6 (C57) and susceptible A/Snell (A/Sn) mice was comparatively studied during the acute phase of infection by Trypanosoma cruzi Y strain. A decline was observed in bone marrow eosinophil levels in A/Sn, but not in C57 mice, soon after infection, those of the former remaining significantly below those of the latter up to the 4th day of infection. Bone marrow eosinophil levels of C57 mice declined subsequently to levels comparable to those of A/Sn mice, the number of these cells in this compartment remaining 50% those of non infected controls, in both strains, up to the end of the experiment on the 14th day of infection. The fluctuations in eosinophil levels in blood and peritoneal space were similar in both mice strains studied. Concomitantly with depletion of eosinophils in the marrow, depletion in blood and a marked rise of these cells in the peritoneal space. initial site of infection, occurred in both strains. The difference in eosinophil bone marrow levels, between C57 and A/Sn mice, observed in the first four days of infection, suggests a higher eosinopoiesis capacity of the former in this period, which might contribute to their higher resistance to T. cruzi infection.
在克氏锥虫Y株感染的急性期，对具有抗性的C57B1/6（C57）小鼠和易感的A/Snell（A/Sn）小鼠骨髓、血液和腹腔渗出液中的嗜酸性粒细胞动态变化进行了比较研究。感染后不久，观察到A/Sn小鼠骨髓嗜酸性粒细胞水平下降，但C57小鼠没有，前者的水平在感染第4天之前一直显著低于后者。随后，C57小鼠骨髓嗜酸性粒细胞水平下降至与A/Sn小鼠相当的水平，在感染第14天实验结束时，这两个品系该区域的这些细胞数量均为未感染对照的50%。所研究的两种小鼠品系血液和腹腔空间中嗜酸性粒细胞水平的波动相似。与骨髓中嗜酸性粒细胞的消耗同时发生的是，血液中的嗜酸性粒细胞减少，而在腹腔空间（感染的初始部位）这些细胞显著增加，这在两个品系中均有发生。在感染的前四天观察到的C57和A/Sn小鼠骨髓嗜酸性粒细胞水平的差异表明，在此期间前者具有更高的嗜酸性粒细胞生成能力，这可能有助于它们对克氏锥虫感染具有更高的抗性。
