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[氟中毒:机制、症状与治疗]

[Fluoride poisoning: mechanism, symptoms and treatment].

作者信息

Vierrou A M, Kavvadia K, Dratsa I

出版信息

Odontostomatol Proodos. 1989 Feb;43(1):31-9.

PMID:2518042
Abstract

The use of fluorides in doses recommended by the International Dental Association is totally safe. Fluoride toxicity occurs only when these doses are exceeded. The human organism is capable of metabolizing fluoride when administered in low doses. Toxic doses though can cause signs and symptoms which vary from simple gastric disturbances to serious health problems or even death. The least fluoride dose which can cause signs and symptoms of fluoride poisoning is called possibly toxic dose. In the present paper the amount of 5 mgF-/kg is considered as the probably toxic dose of fluoride. In the case of accidental ingestion of a fluoride overdose the dentist should be also to calculate the amount of fluoride ingested. A simple method of calculating the amount of fluoride swallowed is presented in this paper. In addition the emergency treatment for fluoride overdoses is discussed. The danger of acute fluoride poisoning has increased lately, especially for children, due to the variety, pleasant taste smell and colour of fluoride products. Dentists should be able to estimate the toxic potential of fluoride in case of accidental poisoning and advise appropriate treatment.

摘要

按照国际牙科协会推荐剂量使用氟化物是完全安全的。只有当超过这些剂量时才会发生氟中毒。人体能够在低剂量摄入氟化物时对其进行代谢。然而,中毒剂量会导致各种症状,从简单的胃部不适到严重的健康问题甚至死亡。能够引起氟中毒症状的最低氟化物剂量被称为可能中毒剂量。在本文中,5毫克氟/千克的量被视为氟化物的可能中毒剂量。如果意外摄入过量氟化物,牙医还应计算摄入的氟化物量。本文介绍了一种计算吞咽氟化物量的简单方法。此外,还讨论了氟化物过量的紧急治疗方法。由于氟化物产品种类繁多、味道宜人、气味好闻且颜色多样,急性氟中毒的危险近来有所增加,尤其是对儿童而言。牙医应能够在意外中毒情况下估计氟化物的潜在毒性并建议适当的治疗方法。

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