[Arterial pressure variation following an intravenous and submucous injection of local anaesthetic solutions with vasoconstrictor].

This paper deals with the control, registration and statistical evaluation of blood pressure variations (systolic, diastolic and average) after an i.v. and submucous injection of fixed quantity local anaesthetic solutions (0.05 ml) in white hamsters. The solutions used were: lidocaine 2% with adrenaline 1/80,000, lidocaine 3% with noradrenaline 1/25,000. The intravenous injection of all three local anaesthetic solutions has caused an increase of the arterial pressure parameters which was statistically significant (P less than 0.01). The submucous injection of lidocaine 2% solution with adrenaline 1/80,000 and lidocaine 2% with noradrenaline 1/80,000 has not caused mentionworthy arterial pressure variations. On the contrary, the submucous injection of lidocaine 3% solution with noradrenaline 1/25,000 has led to an increase of the arterial pressure which is statistically important (P less than 0.05). The research results have led to the following conclusions: 1) Intravascular injection of local anaesthetics with adrenaline or noradrenaline has immediate negative consequences on the circulatory system, a fact which renders necessary a test respiration prior to any stem anaesthesia. 2) The submucous injection of lidocaine solutions with adrenaline or noradrenaline 1/80,000 may be described as harmless with respect to cardiovascular toxicity, and 3) The 3% lidocaine solution with noradrenaline 1/25,000 has proved to be capable of producing significant increase of the arterial pressure following a submucous injection. Anaesthetic solutions with 1/25,000 noradrenaline concentration should not be used, while they must be considered as extremely hazardous for patients with cardiovascular problems.