Andronikaki-Faldami A, Nikolatou O, Nikolopoulou-Papaconstantinou A, Psaroulis K
Odontostomatol Proodos. 1989 Aug;43(4):365-71.
Two cases of gingival hyperplasia associated with the administration of nifedipine are presented in this paper. Case 1, a 66 years old woman appeared with severe gingival enlargement, which was located at the right anterior and premolar region. Both attached gingivae and interdental papillae were hyperplastic, and the enlargement was more pronounced at the labial surfaces. The patient discontinued nifedipine, and after scaling and root planning, gingivectomy was performed. One month postoperatively the gingivae were in perfect health. Case 2, a 68 years old man presented with gingival enlargement mainly of the interdental papillae of the anterior and posterior region, which was more pronounced at the labial surfaces. Gingivectomy was performed at the upper anterior region after deep scaling, but the patient did not discontinue nifedipine. Three weeks postoperatively, recurrence of hyperplasia was noticed. In both cases histologically the gingival epithelium was parakeratininized and exhibited elongated rete pegs. The underlying connective tissue comprised of dense collagen fibres and the inflammatory cells which were present in the connective tissue, were mainly plasma cells and lymphocytes.
本文报告两例与硝苯地平给药相关的牙龈增生病例。病例1，一名66岁女性，出现严重的牙龈肿大，位于右前牙和前磨牙区。附着龈和牙间乳头均增生，唇面肿大更明显。患者停用硝苯地平，在进行龈上洁治和根面平整后，实施了牙龈切除术。术后1个月牙龈完全恢复健康。病例2，一名68岁男性，主要表现为前后牙区牙间乳头的牙龈肿大，唇面更明显。在进行深度洁治后，对上颌前部区域实施了牙龈切除术，但患者未停用硝苯地平。术后3周，发现增生复发。在两例病例中，组织学检查显示牙龈上皮不全角化， rete钉伸长。其下方的结缔组织由致密的胶原纤维组成，结缔组织中存在的炎症细胞主要是浆细胞和淋巴细胞。
