Bonhin Rodrigo Gonzalez, Carvalho Guilherme Machado de, Guimarães Alexandre Caixeta, Chone Carlos Takahiro, Crespo Agrício Nubiato, Altemani Albina Messias de Almeida Milani, Amstalden Eliane M I
Discipline of Otorhinolaryngology, Head and Neck, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Discipline of Otorhinolaryngology, Head and Neck, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Braz J Otorhinolaryngol. 2014 Jul-Aug;80(4):290-5. doi: 10.1016/j.bjorl.2014.05.016. Epub 2014 Jun 11.
Squamous cell carcinoma is the most common neoplasm of the larynx and glottis, and its prognosis depends on the size of the lesion, level of local invasion, cervical lymphatic spread, and presence of distant metastases. Ki-67 (MKI67) is a protein present in the core, whose function is related to cell proliferation.
To evaluate the expression of marker Ki-67 in squamous cell carcinoma of the larynx and glottis and its correlation to pathological findings.
Experimental study with immunohistochemistry analysis of Ki-67, calculating the percentage of the cell proliferation index in glottic squamous cell carcinomas.
Sixteen cases were analyzed, with six well-differentiated and 10 poorly/moderately differentiated tumors. There was a correlation between cell proliferation index and degree of cell differentiation, with higher proliferation in poorly/moderately differentiated tumors.
The cell proliferation index, as measured by Ki-67, may be useful in the characterization of histological degree in glottic squamous cell tumors.
鳞状细胞癌是喉和声门最常见的肿瘤，其预后取决于病变大小、局部浸润程度、颈部淋巴转移情况以及远处转移的存在。Ki-67（MKI67）是一种存在于细胞核中的蛋白质，其功能与细胞增殖有关。
评估Ki-67标志物在喉和声门鳞状细胞癌中的表达及其与病理结果的相关性。
采用免疫组织化学分析Ki-67的实验研究，计算声门鳞状细胞癌的细胞增殖指数百分比。
分析了16例病例，其中6例为高分化肿瘤，10例为低分化/中分化肿瘤。细胞增殖指数与细胞分化程度之间存在相关性，低分化/中分化肿瘤的增殖程度更高。
通过Ki-67测量的细胞增殖指数可能有助于声门鳞状细胞肿瘤组织学程度的特征化。
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