Stolfi V M, Rossi P, Bacaro D, Quintigliano D, Montemurro A
G Chir. 1989 Nov;10(11):641-5.
Primary malignant lymphoma of the thyroid is a very uncommon disease and represents approximately 5% of all thyroid malignant neoplasms. The Authors report a case whose clinical and histopathological features are discussed and compared with those of previously published series. Primary malignant lymphomas raise a number of issues: abrupt onset, age and sex patterns, histological typing (virtually 100% of cases are non-Hodgkin lymphomas), differential diagnosis with either Hashimoto's chronic thyroiditis (often associated with thyroid primary lymphomas) or genuine anaplastic carcinoma of the thyroid. Routine histological study can be complemented by immunohistochemistry. The treatment of choose is total thyroidectomy plus radiotherapy in cases where radical surgery is possible, or radiotherapy alone which usually carries good results.
原发性甲状腺恶性淋巴瘤是一种非常罕见的疾病，约占所有甲状腺恶性肿瘤的5%。作者报告了一例病例，并对其临床和组织病理学特征进行了讨论，并与先前发表的系列病例进行了比较。原发性恶性淋巴瘤引发了许多问题：起病急、年龄和性别模式、组织学类型（几乎100%的病例为非霍奇金淋巴瘤）、与桥本氏慢性甲状腺炎（常与甲状腺原发性淋巴瘤相关）或真正的甲状腺间变性癌的鉴别诊断。常规组织学研究可通过免疫组织化学加以补充。在可行根治性手术的病例中，首选的治疗方法是全甲状腺切除术加放疗，或单独放疗，通常效果良好。
