Landry Markita P, Kruss Sebastian, Nelson Justin T, Bisker Gili, Iverson Nicole M, Reuel Nigel F, Strano Michael S
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA.
Sensors (Basel). 2014 Sep 2;14(9):16196-211. doi: 10.3390/s140916196.
Advancements in optical nanosensor development have enabled the design of sensors using synthetic molecular recognition elements through a recently developed method called Corona Phase Molecular Recognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications.
光学纳米传感器开发的进展使得通过一种最近开发的称为电晕相分子识别（CoPhMoRe）的方法，利用合成分子识别元件设计传感器成为可能。基于这些设计原则产生的合成传感器对特定分析物具有高度选择性，并在各种条件下使用时表现出显著的稳定性。纳米传感器开发的一个关键要素取决于理解纳米颗粒与围绕纳米传感器的相关电晕相之间界面的能力，这是传统表征工具（如核磁共振）范围之外的一种环境。本综述讨论了在体外和体内环境中研究纳米颗粒电晕所需的新策略和仪器。仪器方法必须有能力同时监测纳米传感器的操作和电晕相中的分子变化。为未来应用提供了用于理解CoPhMoRe机制的新工具的详细概述。
