丙烯酸酯与N-叔丁氧羰基异吲哚酮亚胺之间的对映选择性氮杂-Morita-Baylis-Hillman反应：手性3-取代-3-氨基氧化吲哚的不对称构建
Enantioselective aza-Morita-Baylis-Hillman reaction between acrylates and N-Boc isatin ketimines: asymmetric construction of chiral 3-substituted-3-aminooxindoles.
作者信息
Zhao Xuan, Li Tian-Ze, Qian Jing-Ying, Sha Feng, Wu Xin-Yan
机构信息
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
出版信息
Org Biomol Chem. 2014 Oct 28;12(40):8072-8. doi: 10.1039/c4ob01358a.
PMID:25184554
Abstract
The first enantioselective aza-Morita–Baylis–Hillman reaction of acrylates with ketimines derived from isatins has been developed. With 2 mol% of chiral bifunctional phosphine-squaramide 4e, optically active 3-substituted-3-amino-2-oxindoles were obtained in excellent yields with up to 91% ee.
摘要
已开发出丙烯酸酯与异吲哚酮衍生的酮亚胺的首例对映选择性氮杂-Morita-Baylis-Hillman反应。使用2 mol%的手性双功能膦-方酰胺4e，以高达91%的对映体过量（ee）获得了优异产率的光学活性3-取代-3-氨基-2-氧化吲哚。
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