手性磷酸催化吲哚和吡咯与色酮衍生的 N-Boc 亚胺的高对映选择性加成。
The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids.
机构信息
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
出版信息
Chem Commun (Camb). 2012 Aug 18;48(64):8003-5. doi: 10.1039/c2cc33200k. Epub 2012 Jul 6.
PMID:22773055
Abstract
The first asymmetric aza-Friedel-Crafts reaction of indoles and pyrroles with isatin-derived N-Boc ketimines catalyzed by chiral phosphoric acids is reported. In general, derivatives of substituted 3-amino-2-oxindoles were obtained with excellent enantioselectivities and high yields.
摘要
报告了手性磷酸催化的吲哚和吡咯与色酮衍生的 N-Boc 亚胺酮的首例不对称aza-Friedel-Crafts 反应。通常，取代的 3-氨基-2-氧吲哚衍生物以优异的对映选择性和高收率获得。
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