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保留肺动脉瓣环可降低法洛四联症修复术后晚期肺动脉瓣植入的风险。

Pulmonary annulus preservation lowers the risk of late postoperative pulmonary valve implantation after the repair of tetralogy of Fallot.

作者信息

Kim Gwan Sic, Han Seungbong, Yun Tae-Jin

机构信息

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

出版信息

Pediatr Cardiol. 2015 Feb;36(2):402-8. doi: 10.1007/s00246-014-1021-4. Epub 2014 Sep 4.

Abstract

The long-term benefits of pulmonary annulus preservation in tetralogy of Fallot (ToF) repair in patients with a marginally small pulmonary annulus are controversial. We sought to determine whether pulmonary annulus preservation (AP) is superior to transannular patching (TAP) in lowering the risk of pulmonary valve implantation (PVI) long after the repair of ToF. Of the 255 patients who underwent total correction of ToF during infancy between January 1989 and December 2005, 114 patients (AP group = 57, TAP group = 57) were selected by propensity score matching for various preoperative variables, such as age and body weight at operation, sex, pulmonary artery size, pre-repair palliation, anatomical types of ventricular septal defect, and Z-score of pulmonary valve annulus diameter (PVA-Z). The PVA-Z of the AP and TAP groups were -2.3 ± 1.3 and -2.1 ± 1.3, respectively (p = 0.547). The time to PVI was compared between the two groups. The median follow-up duration was 146 months (AP group: 141 months, TAP group: 147 months; p = 0.191). During the follow-up periods, there were 12 reoperations for the relief of right ventricular outflow tract obstruction (RVOTO), eight PVIs, and three late deaths. While freedom from reoperation for RVOTO was comparable between the two groups (p = 0.182), freedom from PVI at postoperative 15 years was significantly lower in the TAP group than in the AP group (74 and 100 %, p = 0.015). In repairing ToF with marginally small pulmonary valve annulus, AP is associated with a lower risk of late postoperative PVI.

摘要

对于肺动脉瓣环略小的法洛四联症(ToF)患者,在ToF修复术中保留肺动脉瓣环的长期益处存在争议。我们试图确定在ToF修复术后很长一段时间内,保留肺动脉瓣环(AP)在降低肺动脉瓣植入(PVI)风险方面是否优于跨瓣环补片(TAP)。在1989年1月至2005年12月期间接受婴儿期ToF根治术的255例患者中,通过倾向评分匹配法,根据各种术前变量(如手术时的年龄和体重、性别、肺动脉大小、修复前的姑息治疗、室间隔缺损的解剖类型以及肺动脉瓣环直径的Z值(PVA-Z)),选取了114例患者(AP组 = 57例,TAP组 = 57例)。AP组和TAP组的PVA-Z分别为-2.3±1.3和-2.1±1.3(p = 0.547)。比较了两组患者至PVI的时间。中位随访时间为146个月(AP组:141个月,TAP组:147个月;p = 0.191)。在随访期间,有12例因右心室流出道梗阻(RVOTO)进行了再次手术,8例进行了PVI,3例晚期死亡。虽然两组因RVOTO再次手术的自由度相当(p = 0.182),但TAP组术后15年无PVI的自由度显著低于AP组(74%和100%,p = 0.015)。在修复肺动脉瓣环略小的ToF时,AP与术后晚期PVI的较低风险相关。

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