Cocco G, Burkart F, Chu D, Follath F
Eur J Clin Pharmacol. 1978 Mar 17;13(1):1-4. doi: 10.1007/BF00606672.
The pharmacological methods used to assess the intrinsic sympathomimetic activity (ISA) of beta-blockers are discussed. The clinical relevance of ISA to respiratory function, peripheral resistance and cardiac function is reviewed. It appears doubtful whether ISA is always of predominant clinical significance and an alternative explanation is offered for many clinical effects observed with certain beta-blockers, e.g. pindolol, oxprenolol, tolamolol, metoprolol, etc. Some effects of these beta-blockers resemble those of labetalol, a new drug with both alpha and beta-blocking activity. Some clinical effects of certain beta-blockers are more likely to be due to alpha-blocking activity than to their ISA.
讨论了用于评估β受体阻滞剂内在拟交感活性（ISA）的药理学方法。综述了ISA与呼吸功能、外周阻力和心脏功能的临床相关性。ISA是否始终具有主要临床意义似乎值得怀疑，并且针对某些β受体阻滞剂（如吲哚洛尔、氧烯洛尔、甲磺胺心定、美托洛尔等）所观察到的许多临床效应提供了另一种解释。这些β受体阻滞剂的一些效应类似于拉贝洛尔（一种具有α和β受体阻滞活性的新药）的效应。某些β受体阻滞剂的一些临床效应更可能是由于α受体阻滞活性而非其ISA。
