Bbukowska D, Serafińska D, Rudowski W, Hoffman S, Olański W, Gardzińska E, Popiel D, Jedrzejczak G, Czarnecka I
Pol Tyg Lek. 1989;44(43-45):924-7.
Polyvalent Pseudomonas aeruginosa vaccine, prepared at the Institute of Hematology from 10 hospital strains isolated from burn wounds, was administered to 32 children with extensive and deep burns. The vaccine was well tolerated. The vaccine produced a high degree of the immunity against Pseudomonas aeruginosa infection. Agglutinin serum titre increased significantly. Vaccination either prevented or inhibited the infection of burn wounds with Pseudomonas aeruginosa in all immunized children. The symptoms of Pseudomonas aeruginosa infection usually disappeared following one or two vaccinations. Bacteriemia caused by P. aeruginosa was not observed in 31 out of 32 children. In the remaining child transient bacteriemia was noted. No septicemia caused by P. aeruginosa was seen. Due to the high efficiency of the polyvalent P. aeruginosa vaccine all burned children with burns exceeding 10% of the total body surface should by vaccinated to prevent the life-threatening infections with Pseudomonas aeruginosa.
由血液学研究所从10株从烧伤创面分离出的医院菌株制备的多价铜绿假单胞菌疫苗，被施用于32名有大面积深度烧伤的儿童。该疫苗耐受性良好。该疫苗产生了高度的针对铜绿假单胞菌感染的免疫力。凝集素血清滴度显著增加。在所有免疫的儿童中，接种疫苗要么预防要么抑制了烧伤创面被铜绿假单胞菌感染。铜绿假单胞菌感染的症状通常在接种一两次疫苗后消失。32名儿童中有31名未观察到由铜绿假单胞菌引起的菌血症。在其余儿童中注意到有短暂菌血症。未见到由铜绿假单胞菌引起的败血症。由于多价铜绿假单胞菌疫苗的高效性，所有烧伤面积超过全身表面积10%的烧伤儿童都应接种疫苗，以预防由铜绿假单胞菌引起的危及生命的感染。
