[Evaluation of in vitro antibiotic sensitivity: critical features of the MIC].
作者信息
Malcangi A, Mineccia C, Martinetto P
机构信息
Istituto di Microbiologia, Università di Torino.
出版信息
G Batteriol Virol Immunol. 1989 Jan-Dec;82(1-12):165-73.
PMID:2518761
Abstract
Current methods for the "in vitro" study of antibiotic activity, as minimum inhibitory concentration, expose bacteria to constant concentrations of antibiotics. The "in vivo" situation is significantly different, since the antibiotic concentration changes with time. Pharmacokinetic models are "in vitro" experimental systems that seek to simulate conditions of exposure of bacteria to antimicrobial agents that exist in blood and tissues. All of these systems are complicated constructions. A new simple "in vitro" kinetic model, based on solid phase growth, is described.
摘要
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