Rolin O, Giraut B, Lartet R, Rousseau-Blanchery J, Bouanchaud D H
Ann Biol Clin (Paris). 1986;44(1):54-7.
An in vitro device is described that allows the study of bactericidal activity of decreasing antibiotic concentrations. This simple and easily set up device was found to be accurate and reliable. The bactericidal kinetics of three antibacterial compounds (cephalothin, norfloxacin and pristinamycin) on Staphylococcus aureus were compared in a system simulating serum concentration and half-life of each antibacterial compound. The results show the importance of pharmacokinetic parameters on antibacterial activity and their usefulness in new antibiotics evaluation.
描述了一种体外装置，可用于研究抗生素浓度降低时的杀菌活性。该装置简单且易于设置，经发现准确可靠。在模拟每种抗菌化合物血清浓度和半衰期的系统中，比较了三种抗菌化合物（头孢噻吩、诺氟沙星和 pristinamycin）对金黄色葡萄球菌的杀菌动力学。结果表明药代动力学参数对抗菌活性的重要性及其在新抗生素评估中的实用性。
