HLA-C和KIR等位基因在人乳头瘤病毒感染及相关宫颈病变中的意义
Implication of HLA-C and KIR alleles in human papillomavirus infection and associated cervical lesions.
作者信息
Rizzo Roberta, Gentili Valentina, Rotola Antonella, Bortolotti Daria, Cassai Enzo, Di Luca Dario
机构信息
Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara , Ferrara, Italy .
出版信息
Viral Immunol. 2014 Nov;27(9):468-70. doi: 10.1089/vim.2014.0017. Epub 2014 Sep 4.
Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 condyloma acuminatum, and 111 invasive cervical cancer (ICC) patients. We showed an increase in HLA-C1/KIR2DL2 and HLA-C1/KIR2DL3 pairs in HPV high-risk infected patients (OR 3.05, 3.24) with ICC (OR 1.33, 3.68). These data suggest HLA-C and KIR typing as risk marker for HPV infection and lesion evolution.
人乳头瘤病毒（HPV）对宿主免疫反应的调节会导致宫颈病变。特别是，自然杀伤（NK）细胞对HPV的控制至关重要。由于特定的HLA-I/KIR相互作用会改变NK细胞的激活，我们分析了150名对照者、33名尖锐湿疣患者和111名浸润性宫颈癌（ICC）患者中HPV感染及病变发展过程中的HLA-C和KIR等位基因。我们发现，在HPV高危感染的ICC患者中，HLA-C1/KIR2DL2和HLA-C1/KIR2DL3配对增加（比值比分别为3.05、3.24），在ICC患者中也增加（比值比分别为1.33、3.68）。这些数据表明，HLA-C和KIR分型可作为HPV感染和病变演变的风险标志物。
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