从紫草中分离得到的两种具有神经氨酸酶抑制活性的新型二聚萘醌。
Two new dimeric naphthoquinones with neuraminidase inhibitory activity from Lithospermum erythrorhizon.
作者信息
Yang Yanqin, Zhao Dapeng, Yuan Kailong, Zhou Guojun, Wang Yu, Xiao Yanmeng, Wang Chenxu, Xu Jingwei, Yang Wei
机构信息
a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , P.R. China.
出版信息
Nat Prod Res. 2015;29(10):908-13. doi: 10.1080/14786419.2014.957695. Epub 2014 Sep 5.
The crude methanol extract of roots of Lithospermum erythrorhizon was subjected to successive chromatographic fractionation which afforded two new dimeric naphthoquinone derivatives shikometabolin E (2) and shikometabolin F (3) as well as one known compound shikometabolin A (1). The structures of compounds 1-3 were elucidated by using UV, MS, 1D and 2D NMR spectroscopic analysis. The two new dimeric naphthoquinone derivatives showed significant neuraminidase inhibitory activities.
对紫草根部的粗甲醇提取物进行连续色谱分离，得到了两种新的二聚萘醌衍生物紫草新代谢物E（2）和紫草新代谢物F（3）以及一种已知化合物紫草新代谢物A（1）。通过紫外光谱、质谱、一维和二维核磁共振光谱分析确定了化合物1 - 3的结构。这两种新的二聚萘醌衍生物表现出显著的神经氨酸酶抑制活性。
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