来自紫草根部的单胺氧化酶抑制性萘醌类化合物。

Monoamine oxidase inhibitory naphthoquinones from the roots of Lithospermum erythrorhizon.

作者信息

Choi Woo Hoi, Hong Seong Su, Lee Seon A, Han Xiang Hua, Lee Kyong Soon, Lee Myung Koo, Hwang Bang Yeon, Ro Jai Seup

机构信息

College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea and 2Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361-763, Korea.

出版信息

Arch Pharm Res. 2005 Apr;28(4):400-4. doi: 10.1007/BF02977668.

DOI:10.1007/BF02977668

PMID:15918512

Abstract

Activity-guided fractionation of a hexane-soluble extract of the roots of Lithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with IC50 values of 10.0, 13.3, and 59.1 microM, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity.

摘要

采用小鼠脑单胺氧化酶（MAO）抑制试验，对紫草（Lithospermum erythrorhizon）根的己烷可溶提取物进行活性导向分级分离，得到了两种已知的萘醌类化合物乙酰紫草素和紫草素，以及一种呋喃基对苯二酚紫草呋喃E。这些化合物对MAO的抑制中浓度（IC50）值分别为10.0、13.3和59.1微摩尔。虽然乙酰紫草素和紫草素对MAO-A和MAO-B均无特异性，但通过Lineweaver-Burk作图分析表明，其对MAO-A和MAO-B活性的抑制作用均为竞争性抑制。