氯胺酮对新生期地塞米松暴露幼鼠抑郁样行为的抗抑郁作用。
Antidepressant Effects of Ketamine on Depression-like Behavior in Juvenile Mice after Neonatal Dexamethasone Exposure.
机构信息
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. ; National Institute on Drug Dependence, Peking University, Beijing, P.R. China.
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.
出版信息
Clin Psychopharmacol Neurosci. 2014 Aug;12(2):124-7. doi: 10.9758/cpn.2014.12.2.124. Epub 2014 Aug 12.
OBJECTIVE
Pediatric depression is associated with significant functional impairment at school and at work. Recently, we reported on depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a potential animal model for pediatric depression. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has promoted rapid and long-lasting antidepressant effects in patients with treatment-resistant major depression. This study was conducted to examine whether ketamine had antidepressant effects in juvenile mice after neonatal DEX exposure.
METHODS
A single dose (10 mg/kg) of ketamine or vehicle was injected into juvenile mice at days 29-32 after neonatal DEX (or saline) exposure (days 1-3). The sucrose preference test, tail suspension test, and forced swimming test were performed 24, 40, and 46 hours, respectively, after injection of ketamine.
RESULTS
Ketamine (10 mg/kg) significantly improved depression-like behavior in DEX-treated juvenile mice.
CONCLUSION
This finding suggests that ketamine confers antidepressant effects in an animal model of pediatric depression.
目的
儿科抑郁症与在校和在职时的显著功能障碍有关。最近，我们报告了新生期接受地塞米松（DEX）暴露的幼鼠出现类似抑郁的行为，这可能是儿科抑郁症的动物模型。N-甲基-D-天冬氨酸（NMDA）受体拮抗剂氯胺酮在治疗抵抗性重度抑郁症患者中具有快速和持久的抗抑郁作用。本研究旨在探讨氯胺酮在新生期 DEX 暴露后的幼鼠中是否具有抗抑郁作用。
方法
在新生期 DEX（或生理盐水）暴露后第 29-32 天（第 1-3 天），给幼鼠单次注射（10mg/kg）氯胺酮或载体。在注射氯胺酮后 24、40 和 46 小时分别进行蔗糖偏好测试、悬尾测试和强迫游泳测试。
结果
氯胺酮（10mg/kg）显著改善了 DEX 处理的幼鼠的抑郁样行为。
结论
这一发现表明氯胺酮在儿科抑郁症的动物模型中具有抗抑郁作用。
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