吸入性抗菌治疗 - 有效治疗的障碍。
Inhaled antimicrobial therapy - barriers to effective treatment.
机构信息
Novartis Pharmaceuticals Corporation, 150 Industrial Road, San Carlos, CA, USA.
出版信息
Adv Drug Deliv Rev. 2015 May;85:24-43. doi: 10.1016/j.addr.2014.08.013. Epub 2014 Sep 1.
PMID:25193067
Abstract
Inhaled antibiotics dramatically improve targeting of drug to the site of respiratory infections, while simultaneously minimizing systemic exposure and associated toxicity. The high local concentrations of antibiotic may enable more effective treatment of multi-drug resistant pathogens. This review explores barriers to effective treatment with inhaled antibiotics. In addition, potential opportunities for improvements in treatment are reviewed.
摘要
吸入式抗生素可显著提高药物对呼吸道感染部位的靶向性，同时最大限度地减少全身暴露和相关毒性。抗生素的高局部浓度可能使多药耐药病原体的治疗更有效。本文探讨了影响吸入式抗生素有效治疗的障碍。此外，还回顾了改善治疗的潜在机会。
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