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[我国医疗保健中的多发性硬化症:电生理、免疫学及临床分析]

[Multiple sclerosis in health care in our country: electrophysiological, immunological and clinical analysis].

作者信息

Castillo J L, Ruíz F, Lavados J, Alvarez G, Monari M

出版信息

Rev Med Chil. 1989 Oct;117(10):1122-9.

PMID:2519355
Abstract

Among 70 patients referred for suspected multiple sclerosis (MS) a total of 40 met criteria for definite (17), likely (12) or possible (11) diagnosis of the disease. Visual evoked potentials provided evidence of CNS lesion in 13 cases. Abnormalities of somatosensory evoked potentials, particularly on stimulation of the posterior tibial nerve, were present in 90% of patients. Brainstem auditory evoked potentials were of little use, contributing to diagnosis of one subclinical lesion; they were normal in 14 cases with suspected brainstem involvement. A definite diagnosis of MS was made in 4 cases by study of oligoclonal bands. The most frequently involved sites were the optic nerve and the brainstem, followed by the spinal cord. Hemispheral location was demonstrated in only 3 cases. These findings of the first study on MS in our country suggest a different pattern for demyelinating diseases in Chile.

摘要

在70名因疑似多发性硬化症(MS)而转诊的患者中,共有40人符合明确(17例)、可能(12例)或疑似(11例)该疾病的诊断标准。视觉诱发电位在13例中提供了中枢神经系统病变的证据。体感诱发电位异常,尤其是在刺激胫后神经时,90%的患者存在该异常。脑干听觉诱发电位作用不大,仅有助于诊断1例亚临床病变;在14例疑似脑干受累的病例中,其结果均正常。通过寡克隆带研究,4例确诊为MS。最常受累的部位是视神经和脑干,其次是脊髓。仅3例显示半球部位受累。我国首次关于MS的研究结果表明,智利脱髓鞘疾病的模式有所不同。

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