应激诱导的疼痛：新型疗法开发的一个靶点。
Stress-induced pain: a target for the development of novel therapeutics.
作者信息
Johnson Anthony C, Greenwood-Van Meerveld Beverley
机构信息
Veterans Affairs Medical Center (B.G.-V.M.), Department of Physiology (B.G.-V.M.), and Oklahoma Center for Neuroscience (A.C.J., B.G.-V.M.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Veterans Affairs Medical Center (B.G.-V.M.), Department of Physiology (B.G.-V.M.), and Oklahoma Center for Neuroscience (A.C.J., B.G.-V.M.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
出版信息
J Pharmacol Exp Ther. 2014 Nov;351(2):327-35. doi: 10.1124/jpet.114.218065. Epub 2014 Sep 5.
Although current therapeutics provide relief from acute pain, drugs used for treatment of chronic pain are typically less efficacious and limited by adverse side effects, including tolerance, addiction, and gastrointestinal upset. Thus, there is a significant need for novel therapies for the treatment of chronic pain. In concert with chronic pain, persistent stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic pain disorders. Stress exacerbation of chronic pain suggests that centrally acting drugs targeting the pain- and stress-responsive brain regions represent a valid target for the development of novel therapeutics. This review provides an overview of how stress modulates spinal and central pain pathways, identifies key neurotransmitters and receptors within these pathways, and highlights their potential as novel targets for therapeutics to treat chronic pain.
尽管目前的治疗方法可缓解急性疼痛，但用于治疗慢性疼痛的药物通常疗效较差，且受到诸如耐受性、成瘾性和胃肠道不适等不良反应的限制。因此，迫切需要治疗慢性疼痛的新疗法。与慢性疼痛相伴的是，持续的压力会促进疼痛感知并使疼痛通路敏感化，从而导致一个促进慢性疼痛疾病的前馈循环。慢性疼痛的压力加剧表明，针对疼痛和压力反应性脑区的中枢作用药物是开发新疗法的有效靶点。本综述概述了压力如何调节脊髓和中枢疼痛通路，确定了这些通路中的关键神经递质和受体，并强调了它们作为治疗慢性疼痛新靶点的潜力。
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