Ferrara Pietro, De Angelis Maria Chiara, Caporale Olga, Malamisura Monica, Del Volgo Valentina, Vena Flaminia, Gatto Antonio, Chiaretti Antonio
Institute of Pediatric, Catholic University of Sacred Heart, Rome, Italy.
Campus Bio-Medico University, Rome, Italy.
Urol J. 2014 Sep 6;11(4):1777-82.
To describe the natural history of patients with nocturnal enuresis (NE) during a 10-year period and to evaluate possible impact of comorbid conditions on the persistence of NE.
Ninety-five children (male to female ratio [M:F] 65:30), aged at first visit between 6 and 21 years were included in this study. Of study subjects 75 had primary monosymptomatic nocturnal enuresis (PMNE), 3 had secondary monosymptomatic nocturnal enuresis (SMNE) and 17 had non-monosymptomatic nocturnal enuresis (NMNE). Demographic and NE-related details were assessed from electronic medical records and by telephone interview at the times 3, 6, 12 months and 3, 5, 10 years after the first examination. Sixty-seven of 95 patients were enrolled, of whom 57 had PMNE (M:F ratio 39:18, mean age 9.35 ± 2.81 years, mean age at improvement 11.5 ± 4.08 years), 8 had NMNE (M:F ratio 4:4, mean age 10.1 ± 2.64 years, mean age at improvement 12.6 ± 1.68 years) and 2 had SMNE (M:F ratio 1:1, mean age 12 years, mean age at improvement 13.5 ± 2.12 years).
The mean duration of follow up was 7.2 ± 2.5 years. All of the 67 children had 5 years follow up. Only 29 of 67 patients (19 with PMNE, 8 with NMNE and 2 with SMNE) had 10 years follow up and 4 of 19 with PMNE were still affected by NE. Out of 57 patients with PMNE 12 (2/12 with language disorders, 1/12 varicocele and 1/12 cryptorchidism) and out of 8 patients with NMNE 1 were still enuretic while all patients with SMNE were in remission.
We observed that language disorders and testicular pathology in NE children could be comorbidities associated with persistence of NE and treatment resistance.
描述夜间遗尿症（NE）患者10年期间的自然病史，并评估合并症对NE持续存在的可能影响。
本研究纳入了95名儿童（男女比例[M:F]为65:30），首次就诊年龄在6至21岁之间。研究对象中，75例为原发性单纯性夜间遗尿症（PMNE），3例为继发性单纯性夜间遗尿症（SMNE），17例为非单纯性夜间遗尿症（NMNE）。通过电子病历以及在首次检查后3、6、12个月和3、5、10年时进行电话访谈，评估人口统计学和与NE相关的详细信息。95例患者中有67例被纳入研究，其中57例为PMNE（男女比例39:18，平均年龄9.35±2.81岁，改善时平均年龄11.5±4.08岁），8例为NMNE（男女比例4:4，平均年龄10.1±2.64岁，改善时平均年龄12.6±1.68岁），2例为SMNE（男女比例1:1，平均年龄12岁，改善时平均年龄13.5±2.12岁）。
平均随访时间为7.2±2.5年。67名儿童均进行了5年随访。67例患者中只有29例（19例PMNE、8例NMNE和2例SMNE）进行了10年随访，19例PMNE中有4例仍受NE影响。57例PMNE患者中有12例（语言障碍2例、精索静脉曲张1例、隐睾症1例），8例NMNE患者中有1例仍有遗尿现象，而所有SMNE患者均已缓解。
我们观察到NE儿童的语言障碍和睾丸病理可能是与NE持续存在及治疗抵抗相关的合并症。
