Rijnbeek Peter R, van Herpen Gerard, Bots Michiel L, Man Sumche, Verweij Niek, Hofman Albert, Hillege Hans, Numans Matthijs E, Swenne Cees A, Witteman Jacqueline C M, Kors Jan A
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Electrocardiol. 2014 Nov-Dec;47(6):914-21. doi: 10.1016/j.jelectrocard.2014.07.022. Epub 2014 Aug 2.
To establish an up-to-date and comprehensive set of normal values for the clinically current measurements in the adult ECG, covering all ages for both sexes.
The study population included 13,354 individuals, taken from four population studies in The Netherlands, ranging in age from 16 to 90 years (55% men) and cardiologically healthy by commonly accepted criteria. Standard 12-lead ECGs were available for all participants. The ECGs were processed by a well-validated computer program. Normal limits were taken as the 2nd and 98th percentiles of the measurement distribution per age group.
Our study corroborates many findings of previous studies, but also provides more differentiated results, in particular for the older age groups. Age trends were apparent for the QTc interval, QRS axis, and indices of left ventricular hypertrophy. Amplitudes in the left precordial leads showed a substantial increase in the older age groups for women, but not for men. Sex-dependent differences were apparent for most ECG parameters. All results are available on the Website www.normalecg.org, both in tabular and in graphical format.
We determined age- and sex-dependent normal values of the adult ECG. Our study distinguishes itself from other studies by the large size of the study population, comprising both sexes, the broad range of ages, and the exhaustive set of measurements. Our results emphasize that most diagnostic ECG criteria should be age- and sex-specific.
建立一套最新且全面的成人心电图临床当前测量正常值，涵盖所有年龄段的男性和女性。
研究人群包括13354人，取自荷兰的四项人群研究，年龄范围为16至90岁（55%为男性），且根据公认标准心脏健康。所有参与者均有标准12导联心电图。心电图由一个经过充分验证的计算机程序处理。正常范围取各年龄组测量分布的第2百分位数和第98百分位数。
我们的研究证实了先前研究的许多发现，但也提供了更具差异性的结果，尤其是对于老年人群体。QTc间期、QRS轴和左心室肥厚指数存在明显的年龄趋势。女性老年组左胸前导联的振幅大幅增加，而男性则没有。大多数心电图参数存在明显的性别差异。所有结果均可在网站www.normalecg.org上以表格和图形形式获取。
我们确定了成人心电图的年龄和性别依赖性正常值。我们的研究因其研究人群规模大、涵盖两性及广泛年龄范围以及详尽的测量项目而有别于其他研究。我们的结果强调，大多数诊断性心电图标准应针对年龄和性别。
