Herz Daniel, Karl Sebastian, Weiß Johannes, Zimmermann Paul, Haupt Sandra, Zimmer Rebecca Tanja, Schierbauer Janis, Wachsmuth Nadine Bianca, Erlmann Maximilian Paul, Niedrist Tobias, Khoramipour Kayvan, Voit Thomas, Rilstone Sian, Sourij Harald, Moser Othmar
Division of Exercise Physiology and Metabolism, BaySpo-Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.
Department of Cardiology, Klinikum Bamberg, 96049 Bamberg, Germany.
Nutrients. 2024 Apr 10;16(8):1114. doi: 10.3390/nu16081114.
The effects of intermittent fasting (IF) on health promotion in the healthy population remain controversial. Therefore, our study aimed to analyse the efficacy and feasibility of different IF protocols and evaluated the effects within a cohort with a controlled-run in phase on the body mass index (BMI) as the primary outcome, the body composition, and metabolic and haematological markers in healthy participants. A total of 25 individuals were randomised into three fasting groups: 16/8 fasting ( = 11), 20/4 fasting ( = 6), and alternate-day fasting (ADF, = 8). Assessments were conducted at baseline (visit 1), after a four-week controlled-run in phase (visit 2), and after eight weeks of fasting (visit 3). Both the BMI ( = 0.01) and bodyweight ( = 0.01) were significantly reduced in the ADF group, which was not seen in the 16/8 and 20/4 groups ( > 0.05). Adherence was different but not statistically among the groups (16/8: 84.5 ± 23.0%; 20/4: 92.7 ± 9.5%; and ADF: 78.1 ± 33.5%, = 0.57). Based on our obtained results, the data suggest that some fasting interventions might be promising for metabolic health. However, adherence to the specific fasting protocols remains challenging even for the healthy population.
间歇性禁食（IF）对健康人群促进健康的作用仍存在争议。因此，我们的研究旨在分析不同间歇性禁食方案的有效性和可行性，并在一个队列中进行对照预试验阶段，以体重指数（BMI）作为主要结局指标，评估其对健康参与者身体成分、代谢和血液学指标的影响。共有25名个体被随机分为三个禁食组：16/8禁食组（n = 11）、20/4禁食组（n = 6）和隔日禁食组（ADF，n = 8）。在基线期（第1次访视）、四周对照预试验阶段后（第2次访视）和八周禁食后（第3次访视）进行评估。ADF组的BMI（P = 0.01）和体重（P = 0.01）均显著降低，而16/8禁食组和20/4禁食组未见此现象（P > 0.05）。各组的依从性有所不同，但无统计学差异（16/8禁食组：84.5 ± 23.0%；20/4禁食组：92.7 ± 9.5%；ADF组：78.1 ± 33.5%，P = 0.57）。根据我们获得的结果，数据表明一些禁食干预措施可能对代谢健康有前景。然而，即使对于健康人群，坚持特定的禁食方案仍然具有挑战性。
