Surowiak Pawel, Gansukh Tserenchunt, Donizy Piotr, Halon Agnieszka, Rybak Zbigniew
Department of Histology and Embryology, Wroclaw Medical University, Wrocław, Poland; Polish Association of Aesthetic and Anti-Aging Medicine, PTL, Warsaw, Poland; DermaMed Institute of Aesthetic Medicine, Wrocław, Poland.
J Cosmet Dermatol. 2014 Sep;13(3):195-201. doi: 10.1111/jocd.12103.
Interleukins and NFκ-B are involved in the development of inflammatory reactions. It has been suggested that these proteins are important contributing factors in the process of photoaging of skin. Moreover, interleukins and NFκ-B are known to be capable of inducing expression of cyclooxygenase 2 (COX-2). Expression of COX-2 in various populations of skin cells has not been examined in the specific processes of aging.
The study aimed at evaluating COX-2 expression in skin samples originating from patients with chronologically aged and photoaged skin at various stages of skin aging.
Immunohistochemical analysis of COX-2 reactivity was conducted on samples originating from 52 women undergoing surgery for reasons other than skin pathology.
Our study demonstrated that COX-2 expression in keratinocytes and fibroblasts was significantly higher in skin samples affected by photoaging than in samples affected by endogenous aging or obtained from younger individuals.
The results indicate that COX-2 may be involved in the pathogenesis of the photoaging process. Inhibition of expression or activity of the enzyme may find application in photoaging treatment and/or prophylaxis.
白细胞介素和核因子κB参与炎症反应的发生发展。有研究表明，这些蛋白质是皮肤光老化过程中的重要促成因素。此外，已知白细胞介素和核因子κB能够诱导环氧合酶2（COX-2）的表达。在皮肤老化的特定过程中，尚未对各种皮肤细胞群体中COX-2的表达进行研究。
本研究旨在评估在不同皮肤老化阶段，取自自然老化和光老化患者的皮肤样本中COX-2的表达情况。
对52名因非皮肤病理原因接受手术的女性的样本进行COX-2反应性的免疫组织化学分析。
我们的研究表明，与受自然老化影响的样本或取自年轻个体的样本相比，受光老化影响的皮肤样本中角质形成细胞和成纤维细胞的COX-2表达显著更高。
结果表明COX-2可能参与光老化过程的发病机制。抑制该酶的表达或活性可能在光老化治疗和/或预防中得到应用。
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