石蚕叶香科科对肝癌大鼠的显著抗癌活性。
Remarkable Anticancer Activity of Teucrium polium on Hepatocellular Carcinogenic Rats.
作者信息
Movahedi Ariyo, Basir Rusliza, Rahmat Asmah, Charaffedine Mohammad, Othman Fauziah
机构信息
Department of Nutrition and Dietetics, Faculty of Medicine, Universiti Putra Malaysia, Malaysia.
Department of Human Anatomy, Faculty of Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
出版信息
Evid Based Complement Alternat Med. 2014;2014:726724. doi: 10.1155/2014/726724. Epub 2014 Aug 13.
The term cancer has been concomitant with despair, agony, and dreadful death. Like many other diseases, herbal therapy has been used to prevent or suppress cancer. The present study investigated the capability of the decoction of Teucrium polium L. from Lamiaceae family to protect liver cells against hepatocellular carcinoma in carcinogenesis-induced animal model. After 28 weeks of treatment with decoction of Teucrium polium L., serum biochemical markers including ALT, AST, AFP, GGT, ALP, HCY, TNF-α, α2MG, and CBG have been regulated auspiciously. Total antioxidant status also has been increased intensely. Liver lesion score in treated group was lessened and glucocorticoid activity has been intensified significantly. In conclusion, Teucrium polium L. decoction might inhibit or suppress liver cancer development.
癌症这个词一直与绝望、痛苦和可怕的死亡相伴。与许多其他疾病一样，草药疗法已被用于预防或抑制癌症。本研究调查了唇形科植物皱叶香科科水煎剂在致癌诱导动物模型中保护肝细胞免受肝细胞癌侵害的能力。用皱叶香科科水煎剂治疗28周后，血清生化标志物包括谷丙转氨酶（ALT）、谷草转氨酶（AST）、甲胎蛋白（AFP）、γ-谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）、同型半胱氨酸（HCY）、肿瘤坏死因子-α（TNF-α）、α2巨球蛋白（α2MG）和皮质类固醇结合球蛋白（CBG）已得到良好调节。总抗氧化状态也显著增加。治疗组的肝脏病变评分降低，糖皮质激素活性显著增强。总之，皱叶香科科水煎剂可能抑制肝癌的发展。
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