White L, Chan K K, Barrientos A, Gomer C J, Murpheree A L, Benedict W F
Children's Leukaemia and Cancer Research Unit, Prince of Wales Children's Hospital, University of New South Wales, Sydney, Australia.
In Vivo. 1989 Sep-Oct;3(5):315-7.
The role of chemotherapy in the management of retinoblastoma remains unclear. In order to evaluate the responsiveness to conventional or experimental agents, a xenograft model had been developed, where human retinoblastoma is heterotransplanted to the anterior chambers of nude mouse eyes. Because doxorubicin had been found to be ineffective in therapeutic studies utilizing the model, experiments were conducted to evaluate the concentration of the drug in tissues, including intraocular engrafted tumour. The presence of doxorubicin was demonstrated in xenograft containing mouse eyes as well as in tumours of a comparable rabbit model. Distribution in extraocular tissues was consistent with previously published data. It is concluded that failure of response to doxorubicin in the xenograft model is not explained by lack of tumour penetration by the drug.
化疗在视网膜母细胞瘤治疗中的作用仍不明确。为了评估对传统或实验性药物的反应性，已建立了一种异种移植模型，即将人类视网膜母细胞瘤异种移植到裸鼠眼睛的前房。由于在利用该模型进行的治疗研究中发现阿霉素无效，因此进行了实验以评估该药物在包括眼内移植肿瘤在内的组织中的浓度。在含有小鼠眼睛的异种移植以及类似兔模型的肿瘤中均证实了阿霉素的存在。眼外组织中的分布与先前发表的数据一致。得出的结论是，异种移植模型中对阿霉素反应失败不能用药物缺乏肿瘤穿透性来解释。
