Shirahama T, Kayajima T, Ohi Y
Department of Urology, Faculty of Medicine, Kagoshima University, Japan.
In Vivo. 1989 Sep-Oct;3(5):345-9.
IFN-beta was more active than recombinant interferon-alpha (rIFN-alpha) and interferon-gamma (rIFN-gamma) in a human renal cell carcinoma transplanted in nude mice. In 3 out of 5 mice, the tumor completely disappeared and viable tumor cells were not observed at a daily dose of 5 x 10(5) U/mouse. Combination with anti-asialo GM1 antibody did not influence the tumor growth inhibition by IFN-beta. Mononuclear cells around damaged cancer cells were found not to be macrophages. Although the role of mononuclear cells remained unknown, the antitumor activity of IFN-beta seemed to depend on its direct cellular action. IFN-beta may be a useful agent in some renal cell carcinomas.
在移植于裸鼠的人肾细胞癌中，β干扰素比重组α干扰素（rIFN-α）和γ干扰素（rIFN-γ）更具活性。在5只小鼠中有3只，当每日剂量为5×10⁵ U/小鼠时，肿瘤完全消失，未观察到存活的肿瘤细胞。与抗去唾液酸GM1抗体联合使用并不影响β干扰素对肿瘤生长的抑制作用。发现受损癌细胞周围的单核细胞不是巨噬细胞。尽管单核细胞的作用尚不清楚，但β干扰素的抗肿瘤活性似乎取决于其直接的细胞作用。β干扰素可能是某些肾细胞癌的有效药物。
