Myneedu V P, Behera D, Verma A K, Bhalla M, Singh N, Arora J, Singhal R, Mathur M, Lal P, Sarin R
Department of Microbiology, Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Int J Tuberc Lung Dis. 2014 Aug;18(8):958-60. doi: 10.5588/ijtld.13.0328.
The present study was conducted to evaluate the performance of the Xpert(®) MTB/RIF assay and compare Xpert results with solid and MGIT 960 liquid culture system. A total of 134 patients who had failed the Category I or II regimen were recruited for evaluation. Xpert correctly identified all Mycobacterium tuberculosis isolates. The sensitivity and specificity of the Xpert assay for the detection of rifampicin resistance was respectively 98.2% and 97.0% when compared with MGIT 960 results.
本研究旨在评估Xpert(®) MTB/RIF检测的性能，并将Xpert检测结果与固体培养和MGIT 960液体培养系统的结果进行比较。共招募了134例I类或II类治疗方案失败的患者进行评估。Xpert正确鉴定了所有结核分枝杆菌分离株。与MGIT 960结果相比，Xpert检测利福平耐药性的灵敏度和特异性分别为98.2%和97.0%。
