脑正电子发射断层扫描在阿尔茨海默病诊断中的应用
Brain PET in the diagnosis of Alzheimer's disease.
作者信息
Marcus Charles, Mena Esther, Subramaniam Rathan M
机构信息
*Post Doctorate Research Fellow in the Russell H. Morgan, Department of Radiology and Radiological Sciences at Johns Hopkins University in Baltimore, MD; †Nuclear Medicine Resident in the Russell H. Morgan, Department ofRadiology and Radiological Sciences at Johns Hopkins University in Baltimore, MD; ‡Associate Professor in the Russell H. Morgan, Department of Radiology and Radiological Sciences, Department of Oncology, Department of Otolaryngology-Head and Neck Surgery at Johns Hopkins School of Medicine, and the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
出版信息
Clin Nucl Med. 2014 Oct;39(10):e413-22; quiz e423-6. doi: 10.1097/RLU.0000000000000547.
Abstract
OBJECTIVES
The aim of this article was to review the current role of brain PET in the diagnosis of Alzheimer dementia. The characteristic patterns of glucose metabolism on brain FDG-PET can help in differentiating Alzheimer's disease from other causes of dementia such as frontotemporal dementia and dementia of Lewy body. Amyloid brain PET may exclude significant amyloid deposition and thus Alzheimer's disease in appropriate clinical setting.
CONCLUSIONS
FDG-PET and amyloid PET imaging are valuable in the assessment of patients with Alzheimer's disease.
摘要
目的
本文旨在综述脑正电子发射断层扫描（PET）在阿尔茨海默病诊断中的当前作用。脑氟代脱氧葡萄糖（FDG）-PET上葡萄糖代谢的特征模式有助于将阿尔茨海默病与其他痴呆病因（如额颞叶痴呆和路易体痴呆）区分开来。淀粉样蛋白脑PET在适当的临床环境中可排除显著的淀粉样蛋白沉积，从而排除阿尔茨海默病。
结论
FDG-PET和淀粉样蛋白PET成像在阿尔茨海默病患者的评估中具有重要价值。
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本文引用的文献
1
Biological markers of Alzheimer's disease.阿尔茨海默病的生物标志物。
Arq Neuropsiquiatr. 2014 Mar;72(3):227-31. doi: 10.1590/0004-282x20130233.
2
Advances in imaging-genetic relationships for Alzheimer's disease: clinical implications.阿尔茨海默病影像-遗传学关系的进展：临床意义
Neurodegener Dis Manag. 2014;4(1):73-81. doi: 10.2217/nmt.13.68.
3
Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls.阿尔茨海默病患者和对照者脑脊液和血浆中的总载脂蛋白 E 水平及特定同工型组成。
Acta Neuropathol. 2014 May;127(5):633-43. doi: 10.1007/s00401-014-1266-2. Epub 2014 Mar 15.
4
Molecular imaging of Alzheimer disease pathology.阿尔茨海默病病理学的分子成像
AJNR Am J Neuroradiol. 2014 Jun;35(6 Suppl):S12-7. doi: 10.3174/ajnr.A3847. Epub 2014 Feb 6.
5
Glucose metabolism in normal aging and Alzheimer's disease: Methodological and physiological considerations for PET studies.正常衰老和阿尔茨海默病中的葡萄糖代谢：PET研究的方法学和生理学考量
Clin Transl Imaging. 2013 Aug;1(4). doi: 10.1007/s40336-013-0026-y.
6
Disease-modifying drugs in Alzheimer's disease.阿尔茨海默病的疾病修饰药物。
Drug Des Devel Ther. 2013 Dec 6;7:1471-8. doi: 10.2147/DDDT.S41431.
7
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Int J Geriatr Psychiatry. 2014 Jun;29(6):551-61. doi: 10.1002/gps.4036. Epub 2013 Oct 9.
8
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Eur J Nucl Med Mol Imaging. 2014 Feb;41(2):290-300. doi: 10.1007/s00259-013-2564-y. Epub 2013 Oct 2.
9
PET approaches for diagnosis of dementia.用于痴呆症诊断的正电子发射断层扫描（PET）方法。
AJNR Am J Neuroradiol. 2014 Nov-Dec;35(11):2030-8. doi: 10.3174/ajnr.A3695. Epub 2013 Aug 14.
10
Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Amyloid Imaging Task Force of the Alzheimer’s Association and Society for Nuclear Medicine and Molecular Imaging.淀粉样 PET 成像适用标准更新：痴呆症专家、轻度认知障碍和教育。阿尔茨海默病协会和核医学与分子成像学会淀粉样成像工作组。
Alzheimers Dement. 2013 Jul;9(4):e106-9. doi: 10.1016/j.jalz.2013.06.001.
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