Marcus Charles, Mena Esther, Subramaniam Rathan M
*Post Doctorate Research Fellow in the Russell H. Morgan, Department of Radiology and Radiological Sciences at Johns Hopkins University in Baltimore, MD; †Nuclear Medicine Resident in the Russell H. Morgan, Department ofRadiology and Radiological Sciences at Johns Hopkins University in Baltimore, MD; ‡Associate Professor in the Russell H. Morgan, Department of Radiology and Radiological Sciences, Department of Oncology, Department of Otolaryngology-Head and Neck Surgery at Johns Hopkins School of Medicine, and the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Clin Nucl Med. 2014 Oct;39(10):e413-22; quiz e423-6. doi: 10.1097/RLU.0000000000000547.
The aim of this article was to review the current role of brain PET in the diagnosis of Alzheimer dementia. The characteristic patterns of glucose metabolism on brain FDG-PET can help in differentiating Alzheimer's disease from other causes of dementia such as frontotemporal dementia and dementia of Lewy body. Amyloid brain PET may exclude significant amyloid deposition and thus Alzheimer's disease in appropriate clinical setting.
FDG-PET and amyloid PET imaging are valuable in the assessment of patients with Alzheimer's disease.
本文旨在综述脑正电子发射断层扫描（PET）在阿尔茨海默病诊断中的当前作用。脑氟代脱氧葡萄糖（FDG）-PET上葡萄糖代谢的特征模式有助于将阿尔茨海默病与其他痴呆病因（如额颞叶痴呆和路易体痴呆）区分开来。淀粉样蛋白脑PET在适当的临床环境中可排除显著的淀粉样蛋白沉积，从而排除阿尔茨海默病。
FDG-PET和淀粉样蛋白PET成像在阿尔茨海默病患者的评估中具有重要价值。
