Zhang Meng-Xin, Liu Peng-Fei, Zhang Meng-Di, Su Pei-Gen, Shang He-Shan, Zhu Jiang-Tao, Wang Da-Yong, Ji Xin-Ying, Liao Qi-Ming
Department of Microbiology and Immunology, Henan Provincial Research Center of Engineering Technology for Nuclear Protein Medical Detection, Zhengzhou Health College, Zhengzhou, 45000, Henan, China.
Department of Nuclear Medicine, Henan International Joint Laboratory for Nuclear Protein Regulation, The First Affiliated Hospital, Henan University College of Medicine, Ximen St, Kaifeng, 475004, Henan, China.
Ann Nucl Med. 2025 May;39(5):424-440. doi: 10.1007/s12149-025-02031-w. Epub 2025 Mar 13.
Deep learning, a leading technology in artificial intelligence (AI), has shown remarkable potential in revolutionizing nuclear medicine.
This review presents recent advancements in deep learning applications, particularly in nuclear medicine imaging, lesion detection, and radiopharmaceutical therapy.
Leveraging various neural network architectures, deep learning has significantly enhanced the accuracy of image reconstruction, lesion segmentation, and diagnosis, improving the efficiency of disease detection and treatment planning. The integration of deep learning with functional imaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) enable more precise diagnostics, while facilitating the development of personalized treatment strategies. Despite its promising outlook, there are still some limitations and challenges, particularly in model interpretability, generalization across diverse datasets, multimodal data fusion, and the ethical and legal issues faced in its application.
As technological advancements continue, deep learning is poised to drive substantial changes in nuclear medicine, particularly in the areas of precision healthcare, real-time treatment monitoring, and clinical decision-making. Future research will likely focus on overcoming these challenges and further enhancing model transparency, thus improving clinical applicability.
深度学习作为人工智能(AI)的一项前沿技术,在革新核医学方面展现出了巨大潜力。
本综述介绍了深度学习应用的最新进展,特别是在核医学成像、病变检测和放射性药物治疗方面。
利用各种神经网络架构,深度学习显著提高了图像重建、病变分割和诊断的准确性,提高了疾病检测和治疗规划的效率。深度学习与正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)等功能成像技术的整合实现了更精确的诊断,同时促进了个性化治疗策略的发展。尽管前景广阔,但仍存在一些局限性和挑战,特别是在模型可解释性、跨不同数据集的泛化能力、多模态数据融合以及应用中面临的伦理和法律问题方面。
随着技术的不断进步,深度学习有望推动核医学发生重大变革,特别是在精准医疗、实时治疗监测和临床决策等领域。未来的研究可能会集中在克服这些挑战并进一步提高模型透明度,从而提高临床适用性。