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Combined therapy of insulin-producing cells and haematopoietic stem cells offers better diabetic control than only haematopoietic stem cells' infusion for patients with insulin-dependent diabetes.对于胰岛素依赖型糖尿病患者，胰岛素生成细胞与造血干细胞联合治疗比单纯输注造血干细胞能更好地控制糖尿病。
BMJ Case Rep. 2014 Sep 8;2014:bcr2013201238. doi: 10.1136/bcr-2013-201238.
2
Novel therapy for insulin-dependent diabetes mellitus: infusion of in vitro-generated insulin-secreting cells.胰岛素依赖型糖尿病的新型疗法：输注体外生成的胰岛素分泌细胞。
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From Mesenchymal Stromal/Stem Cells to Insulin-Producing Cells: Immunological Considerations.从间充质基质/干细胞到胰岛素分泌细胞：免疫考虑因素。
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Iran J Basic Med Sci. 2020 Feb;23(2):214-223. doi: 10.22038/IJBMS.2019.39582.9387.
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Regenerative and Transplantation Medicine: Cellular Therapy Using Adipose Tissue-Derived Mesenchymal Stromal Cells for Type 1 Diabetes Mellitus.再生与移植医学：使用脂肪组织来源的间充质基质细胞治疗1型糖尿病的细胞疗法
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6
Stem cells to replace or regenerate the diabetic pancreas: Huge potential & existing hurdles.用于替代或再生糖尿病胰腺的干细胞：巨大潜力与现存障碍。
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本文引用的文献

1
Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes.旨在重建1型糖尿病β细胞区室的细胞替代策略。
Diabetes. 2014 May;63(5):1433-44. doi: 10.2337/db13-1742.
2
Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin.人脂肪组织来源的间充质干细胞联合造血干细胞移植可合成胰岛素。
Transplant Proc. 2008 May;40(4):1135-9. doi: 10.1016/j.transproceed.2008.03.113.
3
Reversal of type 1 diabetes in mice.小鼠1型糖尿病的逆转
N Engl J Med. 2006 Jul 6;355(1):89-90. doi: 10.1056/NEJMcibr062559.
4
Stem-cell therapy for diabetes mellitus.糖尿病的干细胞治疗。
Lancet. 2004;364(9429):203-5. doi: 10.1016/S0140-6736(04)16635-X.
5
Autoimmune type 1 diabetes: resolved and unresolved issues.自身免疫性1型糖尿病：已解决和未解决的问题。
J Clin Invest. 2001 Nov;108(9):1247-52. doi: 10.1172/JCI14257.

对于胰岛素依赖型糖尿病患者，胰岛素生成细胞与造血干细胞联合治疗比单纯输注造血干细胞能更好地控制糖尿病。

Combined therapy of insulin-producing cells and haematopoietic stem cells offers better diabetic control than only haematopoietic stem cells' infusion for patients with insulin-dependent diabetes.

作者信息

Dave Shruti D, Trivedi Hargovind L, Gopal Saroj C, Chandra Tulika

机构信息

Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC), Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India.

Department of Nephrology and Transplantation Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC), Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India.

出版信息

BMJ Case Rep. 2014 Sep 8;2014:bcr2013201238. doi: 10.1136/bcr-2013-201238.

DOI:10.1136/bcr-2013-201238
PMID:25199184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4158205/
Abstract

Insulin-dependent diabetes mellitus (IDDM) is a chronic condition characterised by impaired blood sugar metabolism and autoimmunity. We report two children: a 5-year-old girl on exogenous insulin therapy of 30 IU/day and a 9-year-old boy on short-acting insulin 30 IU/day, long-acting insulin 70 IU/day, with IDDM since 4 and 7 years, respectively. We infused in vitro-generated donor bone marrow (BM)-derived haematopoietic stem cells (HSC) in patient 1 and insulin-secreting cells trans-differentiated from autologous adipose tissue-derived mesenchymal stem cells along with BM-HSC in patient 2 under non-myeloablative conditioning. Patient 1 improved during the initial 6 months, but then again lost metabolic control with increased blood sugar levels and insulin requirement of 32 IU/day; we lost her to follow-up after 18 months. Patient 2, over follow-up of 24.87 months, has stable blood sugar levels with glycosylated haemoglobin of 6.4% and present insulin requirement of 15 IU/day.

摘要

胰岛素依赖型糖尿病（IDDM）是一种以血糖代谢受损和自身免疫为特征的慢性疾病。我们报告了两名儿童：一名5岁女孩，每天接受30国际单位的外源性胰岛素治疗；一名9岁男孩，每天接受30国际单位短效胰岛素和70国际单位长效胰岛素治疗，分别患IDDM 4年和7年。在非清髓性预处理条件下，我们将体外生成的供体骨髓（BM）来源的造血干细胞（HSC）输注给患者1，并将从自体脂肪组织来源的间充质干细胞转分化而来的胰岛素分泌细胞与BM-HSC一起输注给患者2。患者1在最初6个月有所改善，但随后血糖水平再次升高，胰岛素需求量增加至每天32国际单位，代谢控制再次丧失；18个月后我们失去了对她的随访。患者2在24.87个月的随访中，血糖水平稳定，糖化血红蛋白为6.4%，目前胰岛素需求量为每天15国际单位。