Srikantharajah Mukunthan, Mahendra Prem, Vydianath Bindu, Lowe Gillian C
School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
Department of Haematology, Centre of Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.
BMJ Case Rep. 2014 Sep 8;2014:bcr2014205470. doi: 10.1136/bcr-2014-205470.
A 23-year-old man presented with a 6-week history of fevers, cervical lymphadenopathy and fatigue. A CT of the neck, chest, abdomen and pelvis showed left cervical lymphadenopathy, enlarged lymph nodes in the axilla and groin and hepatomegaly. A left cervical excisional lymph node biopsy was undertaken and the histopathological findings were consistent with Kikuchi-Fujimoto disease. He was treated with high-dose prednisolone for 1 week, which was then tapered. Generalised arthralgia and daily episodes of malaise were experienced for a subsequent 2 months following the cessation of corticosteroids. The condition lasted 4 months from the onset of symptoms. This case report highlights the importance of including Kikuchi-Fujimoto disease as a differential diagnosis for lymphadenopathy. Kikuchi-Fujimoto disease has commonly been mistaken for tuberculosis and lymphoma, and unnecessary exposure to agents used to treat these conditions can be avoided by prompt histological diagnosis.
一名23岁男性，有6周的发热、颈部淋巴结病和疲劳病史。颈部、胸部、腹部和骨盆的CT显示左颈部淋巴结病、腋窝和腹股沟淋巴结肿大以及肝肿大。进行了左颈部淋巴结切除活检，组织病理学结果符合菊池-藤本病。他接受了高剂量泼尼松龙治疗1周，随后逐渐减量。在停用皮质类固醇后的接下来2个月里，出现了全身性关节痛和每日不适发作。该疾病从症状出现起持续了4个月。本病例报告强调了将菊池-藤本病作为淋巴结病鉴别诊断的重要性。菊池-藤本病常被误诊为结核病和淋巴瘤，通过及时的组织学诊断可以避免不必要地接触用于治疗这些疾病的药物。
