Yu Longhua, Yin Xuntao, Dai Chao, Liang Minglong, Wei Luqing, Li Chuanming, Zhang Jiuquan, Xie Bing, Wang Jian
Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China; Department of Radiology, 401st Hospital of the People׳s Liberation Army, Qingdao, Shandong, China.
Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Brain Res. 2014 Nov 7;1588:135-43. doi: 10.1016/j.brainres.2014.09.005. Epub 2014 Sep 6.
The aim of this study was to investigate possible morphologic changes of the visual cortex in primary open-angle glaucoma (POAG) with varying severity. Twenty normal controls (NC), 19 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Multi-parameter morphologic analyses with regions of interest (V5/MT+, anterior and posterior subregions of V1 and V2) were used to assess the cortical changes among the three groups. Compared with the NC group, decreased cortical thickness was detected in the V5/MT+ area in the MP group and in all of the investigated visual areas except the posterior subregion of V1 in the SP group. Unexpectedly, cortical thinning of the posterior subregion of V2 was detected in the SP group compared with the NC and MP groups. For the other morphologic parameters, only gray matter volume in the posterior subregion of V2 and mean curvature in the V5/MT+ were significantly changed in the SP group. In addition, the clinical measurements were positively correlated with the cortical thickness of the V5/MT+ and the posterior subregion of V2. In conclusion, the V5/MT+ area is involved in early disruption of POAG and the cortical degeneration may be progressive and heterogeneous in different visual cortices. Early neuroprotective therapies on the retina and central visual system may help to preserve vision in patients with POAG.
本研究旨在调查不同严重程度的原发性开角型青光眼（POAG）患者视皮层可能存在的形态学变化。招募了20名正常对照者（NC）、19名轻度（MP）POAG患者和17名重度（SP）POAG患者，并使用磁共振成像进行扫描。采用感兴趣区域（V5/MT+、V1和V2的前后子区域）的多参数形态学分析来评估三组之间的皮层变化。与NC组相比，MP组的V5/MT+区域以及SP组除V1后子区域外的所有研究视区均检测到皮层厚度降低。出乎意料的是，与NC组和MP组相比，SP组检测到V2后子区域的皮层变薄。对于其他形态学参数，仅SP组V2后子区域的灰质体积和V5/MT+的平均曲率有显著变化。此外，临床测量值与V5/MT+和V2后子区域的皮层厚度呈正相关。总之，V5/MT+区域参与了POAG的早期破坏，并且皮层退变在不同视皮层可能是进行性的和异质性的。对视网膜和中枢视觉系统进行早期神经保护治疗可能有助于保护POAG患者的视力。
