Mun Mi Jin, Lee Jin Choon, Lee Byung Joo
Department of Otorhinolaryngology - Head and Neck Surgery, Busan St. Marry's Medical Center, Busan, Republic of Korea.
Department of Otorhinolaryngology - Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University, Busan, Republic of Korea.
Auris Nasus Larynx. 2015 Feb;42(1):59-62. doi: 10.1016/j.anl.2014.08.015. Epub 2014 Sep 6.
Neuroendocrine tumors typically fall into two broad categories: those of epithelial origin and those of neural derivation. The former group includes carcinoid tumors and the latter includes paraganglioma. Although paraganglioma and carcinoid tumor have different biologic behaviors, their overlapping histological appearance can pose diagnostic challenges. Carcinoid tumors are rare, slow-growing neuroendocrine tumors arising from the enterochromaffin cells disseminated throughout the gastrointestinal and bronchopulmonary systems. Carotid body tumor is the most common type of extra-adrenal paraganglioma. Paraganglioma tends to grow slowly but can compress adjacent vessel and nerve. A 63-year-old woman showed huge mass extending from carotid body to skull base, encircling internal and external carotid arteries on magnetic resonance image. Surgical removal of carotid body tumor was done after embolization procedure. Postoperative histopathologic examination and immunohistochemical analysis were consistent with paraganglioma concomitant with carcinoid tumor in carotid body. Primary cervical carcinoid tumor is extremely rare, and to the best of our knowledge, this is the first case of concomitant existence of paraganglioma and carcinoid tumor in carotid body.
上皮起源的肿瘤和神经源性肿瘤。前一组包括类癌肿瘤，后一组包括副神经节瘤。虽然副神经节瘤和类癌肿瘤具有不同的生物学行为，但它们重叠的组织学表现可能带来诊断挑战。类癌肿瘤是罕见的、生长缓慢的神经内分泌肿瘤，起源于分布于整个胃肠道和支气管肺系统的肠嗜铬细胞。颈动脉体瘤是肾上腺外副神经节瘤最常见的类型。副神经节瘤往往生长缓慢，但可压迫相邻血管和神经。一名63岁女性在磁共振成像上显示巨大肿块，从颈动脉体延伸至颅底，包绕颈内和颈外动脉。在栓塞手术后进行了颈动脉体瘤的手术切除。术后组织病理学检查和免疫组化分析结果与颈动脉体副神经节瘤合并类癌肿瘤一致。原发性宫颈类癌肿瘤极为罕见，据我们所知，这是首例颈动脉体副神经节瘤和类癌肿瘤并存的病例。
