住院患者肠道定植耐氟喹诺酮大肠杆菌中131型大肠杆菌的临床和分子流行病学
Clinical and molecular epidemiology of Escherichia coli sequence type 131 among hospitalized patients colonized intestinally with fluoroquinolone-resistant E. coli.
作者信息
Han Jennifer H, Johnston Brian, Nachamkin Irving, Tolomeo Pam, Bilker Warren B, Mao Xiangqun, Clabots Connie, Lautenbach Ebbing, Johnson James R
机构信息
Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
Antimicrob Agents Chemother. 2014 Nov;58(11):7003-6. doi: 10.1128/AAC.03256-14. Epub 2014 Sep 8.
Abstract
This study examined molecular and epidemiologic factors associated with Escherichia coli sequence type 131 (ST131) among hospitalized patients colonized intestinally with fluoroquinolone (FQ)-resistant E. coli between 2002 and 2004. Among 86 patients, 21 (24%) were colonized with ST131. The proportion of ST131 isolates among colonizing isolates increased significantly over time, from 8% in 2002 to 50% in 2004 (P = 0.003). Furthermore, all 19 clonally related isolates were ST131. Future studies should identify potential transmissibility differences between ST131 and non-ST131 strains.
摘要
本研究调查了2002年至2004年间肠道定植有耐氟喹诺酮（FQ）大肠杆菌的住院患者中，与大肠杆菌序列类型131（ST131）相关的分子和流行病学因素。在86例患者中，21例（24%）定植有ST131。随着时间的推移，定植菌株中ST131分离株的比例显著增加，从2002年的8%增至2004年的50%（P = 0.003）。此外，所有19株克隆相关分离株均为ST131。未来的研究应确定ST131与非ST131菌株之间潜在的传播差异。
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