Rahman Masoud, Yu Erick, Forman Evan, Roberson-Mailloux Cameron, Tung Jonathan, Tringe Joseph, Stroeve Pieter
Department of Chemical Engineering and Materials Science, University of California Davis, Davis, CA 95616, USA.
Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Colloids Surf B Biointerfaces. 2014 Oct 1;122:818-822. doi: 10.1016/j.colsurfb.2014.08.013. Epub 2014 Aug 20.
Triblock copolymers comprised of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, or trade name Pluronic) interact with lipid bilayers to increase their permeability. Here we demonstrate a novel application of Pluronic L61 and L64 as modification agents in tailoring the release rate of a molecular indicator species from 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer-coated superparamagnetic Fe3O4/mesoporous silica core-shell nanoparticles. We show there is a direct relationship between the Pluronics' concentration and the indicator molecule release, suggesting Pluronics may be useful for the controlled release of drugs from lipid bilayer-coated carriers.
由聚环氧乙烷-聚环氧丙烷-聚环氧乙烷（PEO-PPO-PEO，商品名普朗尼克）组成的三嵌段共聚物与脂质双层相互作用以增加其通透性。在此，我们展示了普朗尼克L61和L64作为改性剂在调节分子指示剂从1,2-二油酰基-sn-甘油-3-磷酸胆碱（DOPC）双层包覆的超顺磁性Fe3O4/介孔二氧化硅核壳纳米颗粒中释放速率方面的新应用。我们表明普朗尼克的浓度与指示剂分子释放之间存在直接关系，这表明普朗尼克可能有助于从脂质双层包覆的载体中控制药物释放。
