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酪蛋白激酶 1 和 Wnt/β-连环蛋白信号通路。

Casein kinase 1 and Wnt/β-catenin signaling.

机构信息

Division of Molecular Embryology, DKFZ-ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

出版信息

Curr Opin Cell Biol. 2014 Dec;31:46-55. doi: 10.1016/j.ceb.2014.08.003. Epub 2014 Sep 15.

DOI:10.1016/j.ceb.2014.08.003
PMID:25200911
Abstract

Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/β-catenin signaling. They phosphorylate several pathway components and exert a dual function, acting as both Wnt activators and Wnt inhibitors. Recent discoveries suggest that CK1 members act in a coordinated manner to regulate early responses to Wnt and notably that their enzymatic activity is regulated. Here, I provide a brief update of CK1 function and regulation in Wnt/β-catenin signaling.

摘要

酪蛋白激酶 1（CK1）成员在 Wnt/β-连环蛋白信号通路中发挥着关键的和进化保守的作用。它们磷酸化几种途径成分，并发挥双重功能，既是 Wnt 激活剂，又是 Wnt 抑制剂。最近的发现表明，CK1 成员以协调的方式发挥作用，调节对 Wnt 的早期反应，特别是它们的酶活性受到调节。在这里，我将简要介绍 CK1 在 Wnt/β-连环蛋白信号通路中的功能和调节。

相似文献

[1]
Casein kinase 1 and Wnt/β-catenin signaling.

Curr Opin Cell Biol. 2014-9-15

[2]
CK1 in Developmental Signaling: Hedgehog and Wnt.

Curr Top Dev Biol. 2017

[3]
Coordinated action of CK1 isoforms in canonical Wnt signaling.

Mol Cell Biol. 2011-5-23

[4]
Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin.

Cell Signal. 2007-3

[5]
[Dual-role regulations of canonical Wnt/beta-catenin signaling pathway].

Beijing Da Xue Xue Bao Yi Xue Ban. 2010-4-18

[6]
Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ.

Chem Biol. 2011-4-22

[7]
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.

Science. 2013-2-14

[8]
Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways.

EMBO Rep. 2008-12

[9]
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Nat Chem Biol. 2010-10-3

[10]
Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.

J Cell Sci. 2007-2-15

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