Chen Hong, Zou Yang, Yang Hong, Wang Jingjing, Pan Hong
Department of Gynecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.
Int J Oncol. 2014 Dec;45(6):2355-64. doi: 10.3892/ijo.2014.2645. Epub 2014 Sep 9.
FoxM1 is a specific transcription factor that has an important function in aggressive human carcinomas, including cervical cancer. However, the specific function and internal molecular mechanism in cervical cancer remain unclear. In this study, RNAi-mediated FoxM1 knockdown inhibited cell growth. This process also decreased the migration and invasion activities of HeLa cells in vitro. Downregulation of FoxM1 inhibited tumor growth and angiogenesis in vivo. In addition, the expressions of uPA, matrix metalloproteinase (MMP)-2, MMP-9 and VEGF were significantly decreased in vitro and in vivo. These results suggested that the inactivation of FoxM1 could be a novel therapeutic target for cervical cancer treatment.
FoxM1是一种特定的转录因子，在包括宫颈癌在内的侵袭性人类癌症中具有重要作用。然而，其在宫颈癌中的具体功能和内在分子机制仍不清楚。在本研究中，RNA干扰介导的FoxM1基因敲低抑制了细胞生长。这一过程还降低了HeLa细胞在体外的迁移和侵袭活性。FoxM1的下调在体内抑制了肿瘤生长和血管生成。此外，尿激酶型纤溶酶原激活物（uPA）、基质金属蛋白酶（MMP）-2、MMP-9和血管内皮生长因子（VEGF）的表达在体外和体内均显著降低。这些结果表明，FoxM1的失活可能是宫颈癌治疗的一个新的治疗靶点。
