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在青少年特发性脊柱侧弯后路融合术后,患者因素与短期预后不良相关。

Patient factors are associated with poor short-term outcomes after posterior fusion for adolescent idiopathic scoliosis.

作者信息

Basques Bryce A, Bohl Daniel D, Golinvaux Nicholas S, Smith Brian G, Grauer Jonathan N

机构信息

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, 800 Howard Avenue, New Haven, CT, 06510, USA.

出版信息

Clin Orthop Relat Res. 2015 Jan;473(1):286-94. doi: 10.1007/s11999-014-3911-4. Epub 2014 Sep 9.

Abstract

BACKGROUND

Posterior spinal fusion (PSF) is commonly performed for patients with adolescent idiopathic scoliosis (AIS). Identifying factors associated with perioperative morbidity and PSF may lead to strategies for reducing the frequency of adverse events (AEs) in patients and total hospital costs.

QUESTIONS/PURPOSES: What is the frequency of and what factors are associated with postoperative: (1) AEs, (2) extended length of stay (LOS), and (3) readmission in patients with AIS undergoing PSF?

PATIENTS AND METHODS

Patients, aged 11 to 18 years, who underwent PSF for AIS during 2012, were identified from the American College of Surgeons National Surgical Quality Improvement Program® (ACS NSQIP®) Pediatric database. Patient were assessed for characteristics associated with AEs, extended LOS (defined as more than 6 days), and hospital readmission using multivariate logistic regression. Individual AEs captured in the database were grouped into two categories, "any adverse event" (AAE) and "severe adverse events" (SAEs) for analysis. A total of 733 patients met inclusion criteria.

RESULTS

Twenty-seven patients (3.7%) had AAE and 19 patients (2.6%) had SAEs. Both AAE and SAEs were associated with BMI-for-age ninety-fifth percentile or greater (AAE: odds ratio [OR], 3.31; 95% CI, 1.43-7.65; p=0.005. SAE: OR, 3.46; 95% CI, 1.32-9.09; p=0.012). Extended LOS occurred for 60 patients (8.2%) and was associated with greater than 13 levels instrumented (OR, 2.00; 95% CI, 1.11-3.61; p=0.021) and operative time of 365 minutes or more (OR, 2.57; 95% CI, 1.39-4.76; p=0.003). Readmission occurred for 11 patients (1.5%), most often for surgical site infection, and was associated with the occurrence of any complication during the initial hospital stay (OR, 180.44; 95% CI, 35.47-917.97; p<0.001).

CONCLUSIONS

Further research on prevention and management of obesity and surgical site infections may reduce perioperative morbidity for patients with AIS undergoing PSF.

LEVEL OF EVIDENCE

Level III, prognostic study. See Instructions for Authors for a complete description of levels of evidence.

摘要

背景

后路脊柱融合术(PSF)常用于青少年特发性脊柱侧凸(AIS)患者。识别与围手术期发病率及PSF相关的因素可能会带来降低患者不良事件(AE)发生率及医院总成本的策略。

问题/目的:接受PSF的AIS患者术后(1)AE、(2)住院时间延长(LOS)及(3)再入院的发生率及相关因素有哪些?

患者与方法

从美国外科医师学会国家外科质量改进计划®(ACS NSQIP®)儿科数据库中识别出2012年期间因AIS接受PSF的11至18岁患者。使用多因素逻辑回归分析评估患者与AE、住院时间延长(定义为超过6天)及医院再入院相关的特征。数据库中记录的个体AE分为两类,即“任何不良事件”(AAE)和“严重不良事件”(SAE)进行分析。共有733例患者符合纳入标准。

结果

27例患者(3.7%)发生AAE,19例患者(2.6%)发生SAE。AAE和SAE均与年龄别BMI处于第95百分位数或更高相关(AAE:比值比[OR],3.31;95%可信区间[CI],1.43 - 7.65;p = 0.005。SAE:OR,3.46;95% CI,1.32 - 9.09;p = 0.012)。60例患者(8.2%)出现住院时间延长,与固定融合节段超过13个(OR,2.00;95% CI,1.11 - 3.61;p = 0.021)及手术时间365分钟或更长(OR,2.57;95% CI,1.39 - 4.76;p = 0.003)相关。11例患者(1.5%)再次入院,最常见原因是手术部位感染,且与初次住院期间发生任何并发症相关(OR,180.44;95% CI,35.47 - 917.97;p < 0.001)。

结论

对肥胖及手术部位感染的预防和管理进行进一步研究可能会降低接受PSF的AIS患者的围手术期发病率。

证据水平

III级,预后研究。有关证据水平的完整描述见作者指南。

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