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Neuro-oncology: TERT promoter mutations could indicate poor prognosis in glioblastoma.

作者信息

Malkki Hemi

出版信息

Nat Rev Neurol. 2014 Oct;10(10):546. doi: 10.1038/nrneurol.2014.168. Epub 2014 Sep 9.

DOI:10.1038/nrneurol.2014.168
PMID:25201236
Abstract
摘要

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Assessment of MGMT and TERT Subtypes and Prognosis of Glioblastoma by Whole Tumor Apparent Diffusion Coefficient Histogram Analysis.通过全肿瘤表观扩散系数直方图分析评估胶质母细胞瘤的MGMT和TERT亚型及预后
Brain Behav. 2025 Jan;15(1):e70175. doi: 10.1002/brb3.70175.
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Tumor treating fields in glioblastoma: long-term treatment and high compliance as favorable prognostic factors.胶质母细胞瘤中的肿瘤治疗电场:长期治疗和高依从性作为有利的预后因素。
Front Oncol. 2024 Mar 20;14:1345190. doi: 10.3389/fonc.2024.1345190. eCollection 2024.
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The C250T Mutation of Might Grant a Better Prognosis to Glioblastoma by Exerting Less Biological Effect on Telomeres and Chromosomes Than the C228T Mutation.

本文引用的文献

1
Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes.TERT、EGFR和IDH状态的联合分析定义了不同预后的胶质母细胞瘤类别。
Neurology. 2014 Sep 23;83(13):1200-6. doi: 10.1212/WNL.0000000000000814. Epub 2014 Aug 22.
2
TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas.端粒酶逆转录酶(TERT)启动子突变:原发性胶质母细胞瘤中一种新的独立预后因素。
Neuro Oncol. 2015 Jan;17(1):45-52. doi: 10.1093/neuonc/nou158. Epub 2014 Aug 18.
与C228T突变相比,C250T突变对端粒和染色体产生的生物学效应较小,可能会使胶质母细胞瘤的预后更好。
Cancers (Basel). 2024 Feb 9;16(4):735. doi: 10.3390/cancers16040735.
4
Poly(U) binding splicing factor 60 promotes renal cell carcinoma growth by transcriptionally upregulating telomerase reverse transcriptase.多聚(U)结合剪接因子 60 通过转录上调端粒酶逆转录酶促进肾细胞癌生长。
Int J Biol Sci. 2020 Sep 25;16(15):3002-3017. doi: 10.7150/ijbs.45115. eCollection 2020.
5
Characteristics of the isocitrate dehydrogenase gene and telomerase reverse transcriptase promoter mutations in gliomas in Chinese patients.中国人胶质母细胞瘤中异柠檬酸脱氢酶基因和端粒酶逆转录酶启动子突变的特征。
Brain Behav. 2020 Apr;10(4):e01583. doi: 10.1002/brb3.1583. Epub 2020 Mar 8.
6
Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification.超越世界卫生组织浸润性神经胶质瘤分级:神经胶质瘤分类的分子遗传学进展。
Ann Transl Med. 2015 May;3(7):95. doi: 10.3978/j.issn.2305-5839.2015.03.57.