Koestner A
Department of Pathology, Michigan State University, East Lansing 48824.
Probl Vet Med. 1989 Oct-Dec;1(4):516-34.
Canine epilepsy can be classified into primary (idiopathic) and secondary (symptomatic) epilepsy, which is similar to human epilepsy. Primary epilepsy in both species is inherited and characterized by the absence of recognizable causative lesions. Secondary epilepsy is linked to a variety of lesions such as brain tumors, trauma, encephalitis, lysosomal storage diseases, congenital malformations, and metabolic-toxic injury. Correspondingly, various subtypes of secondary epilepsy have been recognized. The pathogenesis of secondary epilepsy is basically associated with selective loss of inhibitory neurons that disturbs the balance between excitation and inhibition.
犬癫痫可分为原发性（特发性）癫痫和继发性（症状性）癫痫，这与人类癫痫相似。两种物种的原发性癫痫都是遗传性的，其特征是没有可识别的致病病变。继发性癫痫与多种病变有关，如脑肿瘤、创伤、脑炎、溶酶体贮积病、先天性畸形和代谢性毒性损伤。相应地，继发性癫痫的各种亚型已得到确认。继发性癫痫的发病机制基本上与抑制性神经元的选择性丧失有关，这种丧失扰乱了兴奋与抑制之间的平衡。
