Gülsoy H Özkan, Gülsoy Nagihan, Calışıcı Rahmi
Department of Metallurgy and Material Engineering, Technology Faculty, Marmara University, Göztepe-Istanbul, Turkey.
Department of Biology, Faculty of Science and Letter, Marmara University, Göztepe-Istanbul, Turkey.
Biomed Mater Eng. 2014;24(5):1861-73. doi: 10.3233/BME-140996.
Titanium and Titanium alloys exhibits properties that are excellent for various bio-applications. Metal injection molding is a processing route that offers reduction in costs, with the added advantage of near net-shape components. Different physical properties of Titanium alloy powders, shaped and processed via injection molding can achieve high complexity of part geometry with mechanical and bioactivity properties, similar or superior to wrought material. This study describes that the effect of particle morphology on the microstructural, mechanical and biocompatibility properties of injection molded Ti-6Al-4V (Ti64) alloy powder for biomaterials applications. Ti64 powders irregular and spherical in shape were injection molded with wax based binder. Binder debinding was performed in solvent and thermal method. After debinding the samples were sintered under high vacuum. Metallographic studies were determined to densification and the corresponding microstructural changes. Sintered samples were immersed in a simulated body fluid (SBF) with elemental concentrations that were comparable to those of human blood plasma for a total period of 15 days. Both materials were implanted in fibroblast culture for biocompatibility evaluations were carried out. The results show that spherical and irregular powder could be sintered to a maximum theoretical density. Maximum tensile strength was obtained for spherical shape powder sintered. The tensile strength of the irregular shape powder sintered at the same temperature was lower due to higher porosity. Finally, mechanical tests show that the irregular shape powder has lower mechanical properties than spherical shape powder. The sintered irregular Ti64 powder exhibited better biocompatibility than sintered spherical Ti64 powder. Results of study showed that sintered spherical and irregular Ti64 powders exhibited high mechanical properties and good biocompatibility properties.
钛及钛合金具有多种优异性能，适用于各种生物应用。金属注射成型是一种能降低成本的加工工艺，还具有近净成形部件的额外优势。通过注射成型加工的钛合金粉末具有不同的物理性能，能够实现具有机械性能和生物活性的高度复杂零件几何形状，与锻造材料相似或更优。本研究描述了颗粒形态对用于生物材料应用的注射成型Ti-6Al-4V（Ti64）合金粉末的微观结构、机械性能和生物相容性的影响。将形状不规则和球形的Ti64粉末与蜡基粘结剂进行注射成型。粘结剂脱脂采用溶剂法和热法。脱脂后，样品在高真空下烧结。通过金相研究确定致密化情况及相应的微观结构变化。将烧结后的样品浸泡在元素浓度与人体血浆相当的模拟体液（SBF）中15天。将两种材料植入成纤维细胞培养物中进行生物相容性评估。结果表明，球形和不规则粉末均可烧结至最大理论密度。球形粉末烧结后获得最大拉伸强度。由于孔隙率较高，相同温度下烧结的不规则形状粉末的拉伸强度较低。最后，力学测试表明不规则形状粉末的机械性能低于球形粉末。烧结后的不规则Ti64粉末比烧结后的球形Ti64粉末表现出更好的生物相容性。研究结果表明，烧结后的球形和不规则Ti64粉末均具有较高的机械性能和良好的生物相容性。
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